Antibiofin

Antibiofin

Antibiofin (natural multifunctional antibiotic; antibacterial, antiviral and antifungal)

COMPOSITION: Antibiofin is a pure natural drug made of highly effective herbs such as Thyme (Thymus vulgaris) and Ajowan (Trachyspermum ammi) and few other herbs. The drug contains an intelligent blend of herbal active ingredients so that its components can strengthen and amplify each other’s therapeutic effects in a synergistic manner. The most important ingredients in the drug are phenolic compounds such as Thymol, Carvacrol, Paracymol and Cineole.

MECHANISM OF ACTION: Antibiofin contains a large amount of terpenoid phenols such as Thymol and Carvacrol. There are a lot of researches indicating that synthetic antibiotic residues in some tissues may remain for a very long time. Therefore, the antibiotics administered for the animal are deposited within the tissues and final food products. Then the drug-contaminated food products are readily transferred into the human body and blood circulation. These drug remnants are responsible for inducing the antibiotic resistance among microbial population which a human host carries within its body. To confront the problem, it was suggested by many scientists to use natural antimicrobials instead of synthetic ones. Therefore, we formulated Antibiofin which contains a large amount of natural terpenoid phenols such as Thymol and Carvacrol.

The natural substance; Thymol is now accepted in the EU standards as an effective antimicrobial agent but safe for humans. Both Thymol and Carvacrol are classified as monoterpenoids, since they have a carbon ring and oxygen (hydroxyl group) functionality. Evidences such as the images of the electron microscope have shown that these two monoterpenoids can be directly enclosed within the cell wall of the bacteria and, by disrupting its structure, increase the permeability of the cell wall of the bacterium. The Thymol and Carvacrol molecules are lipophilic and also have a small molecular size (just a hexagonal carbon ring with a hydroxyl group). Therefore, they are absorbed into the bacterial cellular membrane which is made of two-layer phospholipids and disrupt the structural order of the membrane (i.e. alteration of membrane fatty acids). Thus, the replacement of Thymol and Carvacrol into the cell membrane of the bacteria will mess up the regular structure of the membrane components, and the fatty acids will separate from the membrane. Following these changes and damage to the cell membrane, vital intracellular contents of the bacterial cell such as the metabolites and ions leak out of the damaged membrane. By the direct effect of Thymol and Carvacrol on bacterial cell wall proteins and molecules, shrinkage and coagulation in the bacterial wall will occur and lead bacteria to die.

The most important and deadly effect of Thymol and Carvacrol on bacterial cell wall is their capability to create pores in the membrane structure, which causes the leakage of vital substances from the bacterial cell due to a much higher osmotic pressure within the bacterial cell than the pressure in extracellular matrix. According to recent knowledge, natural antibiotics such as Thymol and Carvacrol have proven antimicrobial effects, and the drugs based on these compounds can prevent the development of various types of respiratory and digestive tract infections in industrial poultry. Actually, industrial poultry experience continuous stress during their growing period. In turn, the reduction of infection in the Antibiofin-treated herd causes the discontinuation of synthetic antibiotics and drugs and, as a result, in organic poultry farms, the chicken can be successfully grown completely without facing with infection challenges. Thymol and Carvacrol are also classified as antioxidants because of their phenolic nature and therefore they are very suitable for use in industrial livestock and poultry farms which are always under the high stressed conditions.

THERAPEUTIC FEATURES: active substances of Antibiofin inhibit the growth and proliferation of bacteria and pathogenic fungi, particularly in the gastrointestinal tract of the poultry. These substances have mild and gradual effects and therefore do not induce drug resistance in bacteria, so the drug can be used to prevent diseases in an optimal way. It can also show a synergistic effect when accompanied with other antibiotics to prevent the progression of the disease.

INDICATIONS:

  • Prevention and treatment of gastrointestinal tract infections and reducing the recovery time
  • Prevention of infectious diseases without inducing drug-resistance
  • Prevention of the progression of the infectious diseases (without interrupting other drugs function, no contraindications)
  • Acts as an effective phytobiotic and growth promoter

TARGET ANIMALS: It can be administered for a variety of birds, including chicken, turkey, quail, partridge, and others.

INSTRUCTIONS TO USE: Please mix 1 liter of drug per 1000 liters of drinking water and use it at least 3 days (every day for 8 hours) according to expert (doctor of veterinary medicine) supervision. Use it in the following conditions:

  • At the first 3 days after the day-old chicks were arrived to the farm
  • When the herd is challenged with an infectious diseases (i.e. digestive tract infections)
  • When the herd experiences a serious stress
  • 24 hours before/after an episode of vaccination to regulate the intestinal flora (as a prebiotic)

CONTRAINDICATIONS: Not to be used in conjunction with drinking vaccines.

CLINICAL TRIALS:

The antimicrobial effect of the drug was evaluated by microdilution method and subsequent counting the bacterial colony units. We measured and compared the colony unit count in two experimental groups; a group consisting the broiler chickens infected with Salmonella treated with Antibiofin and another group of chick which were treated with a standard drug. We found significant therapeutic effects including reducing the burden of bacterial contamination in the stool, decreasing the relative mortality and increasing the relative weight gain in the group of chickens treated with Antibiofin. Interestingly, the colony count in Antibiofin-treated group was lower than the group treated with a routine drug.